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Viagra® may be the most recognizable medication for erectile dysfunction (ED) worldwide, but since the introduction of two more potent ED medications, Cialis® and Levitra®, in 2003, men have been pondering a crucial question: Which is the most popular and effective ED medication?

The answer might come as a surprise.

How Viagra and Its Counterparts Operate

With a quartet of major drugs and a range of different doses to choose from, determining where to start can be challenging. Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil), and Stendra® (avanafil), along with the lesser-known udenafil, all operate on the same principle: inhibiting phosphodiesterase 5 (PDE5). These PDE5 inhibitors, which include tadalafil, vardenafil, and sildenafil, function by blocking an enzyme in the body that restricts blood flow. Essentially, they remove impediments along the path to increased blood flow in the penis, thereby facilitating an erection.

PDE5 inhibitors are highly effective in helping men with ED attain and sustain an erection. Now that sildenafil, tadalafil, and vardenafil are all available as affordable generics, they have become more prevalent than ever. Nonetheless, they exhibit subtle variations in their molecular structure, which sets them apart from one another.

What’s the Most Popular ED Medication and Why?

Most customers of Rex MD gravitate towards Viagra or Cialis, as these two are widely regarded as the most popular PDE5 inhibitors. Viagra holds this distinction because it was the first ED medication ever approved, way back in 1998, while Cialis has earned its reputation for allowing users to achieve an erection at any time over the next 36 hours.

When these two titans of ED medications are pitted against each other in terms of user preference, the results might be unexpected.

Cialis: The Preferred Choice

In head-to-head comparisons, both men and their partners tend to favor Cialis over Viagra. An analysis conducted in 2017 directly compared Cialis (tadalafil) with Viagra (sildenafil), providing clear insights into why Cialis has become a top choice. This comprehensive analysis examined 16 studies encompassing 5,189 patients, whose ages ranged from 36.9 to 56.2 years.

The findings of this review, and another similar one in 2015, consistently indicated a preference for tadalafil over sildenafil among patients and their partners. In conclusion:

“Tadalafil and sildenafil have been shown to exhibit comparable efficacy, safety, and satisfaction for the treatment of ED, and tadalafil dramatically improved the psychological outcomes. The adherence and persistence rates for tadalafil and sildenafil were equal. Furthermore, both men and women preferred tadalafil to sildenafil for the treatment of ED. Thus, tadalafil may be a better choice for ED treatment.”

But why is Cialis the preferred option for many?

Cialis Lasts Longer

One notable feature of Cialis is its extended duration of action. While Viagra can be taken between 30 minutes and 4 hours before sexual activity, Cialis is typically recommended 60 minutes prior to intercourse. Yet, its effects can persist for up to 36 hours, earning it the colloquial nickname of the “weekend pill.” This extended window alleviates timing pressures and the need for meticulous planning, providing users with greater flexibility.

Potential Mental Health Benefits

According to researchers, opting for tadalafil over sildenafil can also yield psychosocial and psychological benefits for couples. The reduced pressure on timing leads to enhanced overall satisfaction with treatment. Tadalafil boosts sexual confidence more effectively than sildenafil.

Fewer Side Effects

Viagra is often considered the most effective ED medication due to its rapid onset of action. However, there is some evidence suggesting that it might be associated with more side effects than its counterparts. In one analysis, sildenafil exhibited the highest overall rate of adverse events, whereas tadalafil had the lowest rate among all adverse events. In another 2017 study, the overall adverse event rate for tadalafil was found to be similar to that of sildenafil, although the nature of their side effects differed. Both medications showed no significant difference in the rate of headaches, stomach pain, or nasal congestion. However, tadalafil users experienced less facial flushing and more back pain compared to those taking sildenafil.

For those prioritizing sheer effectiveness, Viagra may be the initial choice. Conversely, tadalafil might be more suitable for those aiming to optimize tolerability and effectiveness.

Cost-Effective Options

Fortunately, tadalafil and sildenafil are now both affordable and readily accessible. This accessibility is primarily due to their availability as generic drugs from various manufacturers. When these medications were initially approved two decades ago, their cost was high as they were still branded, fetching prices as exorbitant as $90 per dose.

Today, you can obtain tadalafil affordably through telehealth providers like Rex MD. The process is as simple as completing an online medical questionnaire and participating in a virtual consultation with one of our board-certified physicians. Once approved, your order will be discreetly packaged and delivered to your doorstep.

In conclusion, while Viagra remains an iconic ED medication, Cialis has gained the upper hand in terms of preference due to its prolonged effectiveness, potential mental health benefits, fewer side effects, and cost-effectiveness. The choice ultimately depends on individual preferences and priorities in managing erectile dysfunction.